Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human TRPC5 AA range: 828-878
Specificity
This antibody detects endogenous levels of TRPC5 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.293% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010],
Function
function:Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.,similarity:Belongs to the transient receptor family. STrpC subfamily.,similarity:Contains 2 ANK repeats.,subunit:Interacts with NHERF (By similarity). Interacts with MX1 and RNF24.,tissue specificity:Expressed in brain with higher levels in fetal brain.,
Other name
Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (TRP-5) (hTRP-5) (hTRP5)
Fields
>>Axon guidance;>>GnRH secretion
Human protein sequence Database
Q9UL62
Mouse protein sequence database
Q9QX29
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole.
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