Molecular weight (DA)
85kD
Immunogen
Synthesized peptide derived from human TRPV2 AA range: 493-543
Specificity
This antibody detects endogenous levels of TRPV2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.305% sodium azide.
Dilution rate
WB 1:500-2000; IF/ICC 1:100-500;IP 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008],
Function
function:Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.,PTM:N-glycosylated.,PTM:Phosphorylated by PKA.,similarity:Belongs to the transient receptor family. TrpV subfamily.,similarity:Contains 6 ANK repeats.,subcellular location:Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with RGA.,
Other name
Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1)
Fields
>>NOD-like receptor signaling pathway;>>Inflammatory mediator regulation of TRP channels
Human protein sequence Database
Q9Y5S1
Mouse protein sequence database
Q9WTR1
Rat protein sequence database
Q9WUD2
Cellular localization
Cell membrane ; Multi-pass membrane protein . Cytoplasm . Melanosome . Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .
Tissue expression
Brain,Lymphoblast,Skin,
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