Molecular weight (DA)
85kD
Immunogen
Synthesized peptide derived from human FAM5C AA range: 503-553
Specificity
This antibody detects endogenous levels of FAM5C at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.314% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],
Function
similarity:Belongs to the FAM5 family.,
Gene Name
FAM5C DBCCR1L DBCCR1L1
Other name
Protein FAM5C (DBCCR1-like protein 1)
Human protein sequence Database
Q76B58
Mouse protein sequence database
Q499E0
Rat protein sequence database
Q8K1M7
Cellular localization
Secreted . Mitochondrion .
Tissue expression
Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells. Overexpressed in gonadotropinomas compared to normal pituitarie tissues.
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