Molecular weight (DA)
85kD
Immunogen
Synthesized peptide derived from human SIM1 AA range: 545-595
Specificity
This antibody detects endogenous levels of SIM1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.316% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome. [provided by RefSeq, Jul 2008],
Function
function:Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 1 Single-minded C-terminal domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM1 and ARNT.,
Other name
Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14)
Human protein sequence Database
P81133
Mouse protein sequence database
Q61045
Rat protein sequence database
Cellular localization
Nucleus .
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