Molecular weight (DA)
85kD
Immunogen
Synthesized peptide derived from human S7A14 AA range: 50-100
Specificity
This antibody detects endogenous levels of S7A14 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.341% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene is predicted to encode a glycosylated, cationic amino acid transporter protein with 14 transmembrane domains. This gene is primarily expressed in skin fibroblasts, neural tissue, and primary endothelial cells and its protein is predicted to mediate lysosomal uptake of cationic amino acids. Mutations in this gene are associated with autosomal recessive retinitis pigmentosa. In mice, this gene is expressed in the photoreceptor layer of the retina where its expression increases over the course of retinal development and persists in the mature retina. [provided by RefSeq, Apr 2014],
Function
sequence caution:Translated as Glu.,similarity:Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.,
Gene Name
SLC7A14 KIAA1613
Other name
Probable cationic amino acid transporter (Solute carrier family 7 member 14)
Human protein sequence Database
Q8TBB6
Mouse protein sequence database
Q8BXR1
Rat protein sequence database
Cellular localization
Lysosome membrane ; Multi-pass membrane protein . Exhibits a punctated pattern in the cytoplasm, which partially ovelaps with lysosomes.
Tissue expression
Expressed in skin fibroblasts.
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