Molecular weight (DA)
85kD
Immunogen
Synthesized peptide derived from human TLE3 AA range: 257-307
Specificity
This antibody detects endogenous levels of TLE3 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.343% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013],
Function
alternative products:Experimental confirmation may be lacking for some isoforms,function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 7 WD repeats.,subunit:Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1 and TCF7L2 (By similarity). Binds FOXA2.,tissue specificity:Placenta and lung.,
Other name
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Fields
>>Wnt signaling pathway;>>Notch signaling pathway
Human protein sequence Database
Q04726
Mouse protein sequence database
Q08122
Rat protein sequence database
Q9JIT3
Cellular localization
Nucleus.
Tissue expression
Placenta and lung.
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