Molecular weight (DA)
85kD
Immunogen
Synthesized peptide derived from human YMEL1 AA range: 136-186
Specificity
This antibody detects endogenous levels of YMEL1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.353% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
Function
cofactor:Binds 1 zinc ion per subunit .,function:Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism.,similarity:In the C-terminal section; belongs to the peptidase M41 family.,similarity:In the N-terminal section; belongs to the AAA ATPase family.,
Gene Name
YME1L1 FTSH1 YME1L UNQ1868/PRO4304
Other name
ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1)
Human protein sequence Database
Q96TA2
Mouse protein sequence database
O88967
Rat protein sequence database
Q925S8
Cellular localization
Mitochondrion inner membrane . Mitochondrion .
Tissue expression
High expression in cardiac and skeletal muscle mitochondria.
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