Molecular weight (DA)
85kD
Immunogen
Synthesized peptide derived from human ECEL1 AA range: 200-250
Specificity
This antibody detects endogenous levels of ECEL1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.360% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the M13 family of endopeptidases. Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. Mutations in this gene are associated with autosomal recessive distal arthrogryposis, type 5D. This gene has multiple pseudogenes on chromosome 2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014],
Function
cofactor:Binds 1 zinc ion.,function:May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.,PTM:N-glycosylated.,similarity:Belongs to the peptidase M13 family.,tissue specificity:Highly expressed in the CNS, in particular in putamen, spinal cord, medulla and subthalamic nucleus. A strong signal was also detected in uterine subepithelial cells and around renal blood vessels. Detected at lower levels in amygdala, caudate, thalamus, pancreas and skeletal muscle. Detected at very low levels in substantia nigra, cerebellum, cortex, corpus callosum and hippocampus.,
Gene Name
ECEL1 XCE UNQ2431/PRO4991
Other name
Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein)
Human protein sequence Database
O95672
Mouse protein sequence database
Q9JMI0
Rat protein sequence database
Q9JHL3
Cellular localization
Membrane ; Single-pass type II membrane protein .
Tissue expression
Highly expressed in the CNS, in particular in putamen, spinal cord, medulla and subthalamic nucleus. A strong signal was also detected in uterine subepithelial cells and around renal blood vessels. Detected at lower levels in amygdala, caudate, thalamus, pancreas and skeletal muscle. Detected at very low levels in substantia nigra, cerebellum, cortex, corpus callosum and hippocampus.
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