Immunogen
Synthesized peptide derived from human PACE1 AA range: 519-569
Specificity
This antibody detects endogenous levels of PACE1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012],
Function
domain:The protein kinase domain is predicted to be catalytically inactive.,function:May play a role in regulating cell adhesion/migration complexes in migrating cells.,PTM:May be myristoylated; myristoylation may target it to Golgi compartment.,PTM:Phosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 4 HEAT repeats.,subcellular location:Colocalized with EZR/VIL2, actin and CD44 in lamellipodia.,subunit:Interacts with EZR/VIL2 C-terminal domain.,tissue specificity:Ubiquitously expressed.,
Human protein sequence Database
Q8IZE3
Mouse protein sequence database
Q9DBQ7
Rat protein sequence database
Cellular localization
Cytoplasm . Golgi apparatus . Cell projection, lamellipodium . Colocalized with EZR/VIL2, actin and CD44 in lamellipodia.
Tissue expression
Ubiquitously expressed.
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