Immunogen
Synthesized peptide derived from human IF122 AA range: 956-1006
Specificity
This antibody detects endogenous levels of IF122 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Mutations in this gene cause cranioectodermal dysplasia-1. A related pseudogene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],
Function
similarity:Contains 7 WD repeats.,tissue specificity:Expressed in many tissues. Predominant expression in testis and pituitary.,
Gene Name
IFT122 SPG WDR10 WDR140
Human protein sequence Database
Q9HBG6
Mouse protein sequence database
Q6NWV3
Rat protein sequence database
Cellular localization
Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body . Localizes to photoreceptor connecting cilia. .
Tissue expression
Expressed in many tissues. Predominant expression in testis and pituitary.
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