Immunogen
Synthesized peptide derived from human AHSP AA range: 1-51
Specificity
This antibody detects endogenous levels of AHSP at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1：50-200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a molecular chaperone which binds specifically to free alpha-globin and is involved in hemoglobin assembly. The encoded protein binds to monomeric alpha-globin until it has been transferred to beta-globin to form a heterodimer, which in turn binds to another heterodimer to form the stable tetrameric hemoglobin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
Function
function:Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.,induction:By GATA-1 during erythroid maturation.,similarity:Belongs to the AHSP family.,subunit:Monomer. Forms an heterodimer with free alpha-hemoglobin. Does not bind beta-hemoglobin nor alpha(2)beta(2) hemoglobin A.,tissue specificity:Expressed in blood and bone marrow.,
Human protein sequence Database
Q9NZD4
Mouse protein sequence database
Q9CY02
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Expressed in blood and bone marrow.
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