Immunogen
Synthesized peptide derived from human KDIS AA range: 1023-1073
Specificity
This antibody detects endogenous levels of KDIS at Human/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
domain:The transmembrane domain mediates interaction with NTRK1.,function:Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.,PTM:Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol
Gene Name
KIDINS220 ARMS KIAA1250
Fields
>>Neurotrophin signaling pathway
Human protein sequence Database
Q9ULH0
Mouse protein sequence database
Rat protein sequence database
Q9EQG6
Cellular localization
Membrane ; Multi-pass membrane protein . Late endosome . Localized at late endosome before or after nerve growth factor (NGF) stimulation.
Tissue expression
Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.
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