Immunogen
Synthesized peptide derived from human MAT2B AA range: 23-73
Specificity
This antibody detects endogenous levels of MAT2B at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012],
Function
function:Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine inhibition.,miscellaneous:Its expression in hepatoma cell lines may lead to increase DNA synthesis and thereby participate to cell proliferation.,pathway:Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.,similarity:Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.,subunit:Heterotetramer composed of 2 catalytic alpha subunits (alpha and alpha') (MAT2A) and 1 copy of beta subunit (MAT2B).,tissue specificity:Widely expressed.,
Gene Name
MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995
Fields
>>Cysteine and methionine metabolism;>>Metabolic pathways;>>Biosynthesis of amino acids;>>Biosynthesis of cofactors
Human protein sequence Database
Q9NZL9
Mouse protein sequence database
Q99LB6
Rat protein sequence database
Q5U2R0
Cellular localization
intracellular,nucleus,mitochondrion,cytosol,methionine adenosyltransferase complex,extracellular exosome,
Tissue expression
Widely expressed.
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