Immunogen
Synthesized peptide derived from human HBG1 AA range: 34-84
Specificity
This antibody detects endogenous levels of HBG1 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008],
Function
developmental stage:Expressed until four or five weeks after birth.,disease:Some gamma variants can cause severe jaundice and cyanosis in premature and new born babies.,function:Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.,online information:Human hemoglobin variants and thalassemias,PTM:Acetylation of Gly-2 converts Hb F to the minor Hb F1.,similarity:Belongs to the globin family.,subunit:Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F). In the case of deletions affecting one or more of the alpha chains the excess gamma chains form homotetramers that exhibit neither Bohr effect nor heme-heme cooperativity (hemoglobin Bart's).,tissue specificity:Red blood cells.,
Human protein sequence Database
P69891
Mouse protein sequence database
Rat protein sequence database
Cellular localization
cytosol,hemoglobin complex,
Tissue expression
Red blood cells.
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