Immunogen
Synthesized peptide derived from human BHE40 AA range: 229-279
Specificity
This antibody detects endogenous levels of BHE40 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014],
Function
function:May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway.,PTM:Ubiquitinated; which may lead to proteasomal degradation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 Orange domain.,subunit:Able to homodimerize or heterodimerize with TCF3/E47. Interacts with ubiquitin-conjugating enzyme UBE2I/UBC9.,tissue specificity:Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach.,
Gene Name
BHLHE40 BHLHB2 DEC1 SHARP2 STRA13
Fields
>>Circadian rhythm
Human protein sequence Database
O14503
Mouse protein sequence database
O35185
Rat protein sequence database
O35780
Cellular localization
Cytoplasm . Nucleus . Predominantly localized in the nucleus (PubMed:11278694). .
Tissue expression
Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach.
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