Immunogen
Synthesized peptide derived from human NUCB1 AA range: 54-104
Specificity
This antibody detects endogenous levels of NUCB1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010],
Function
domain:The EF-hand domains are unfolded in the absence of Ca(2+) and fold upon Ca(2+) addition.,function:Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis.,miscellaneous:Discovered as DNA-binding protein in the serum of lupus-prone mice.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the nucleobindin family.,similarity:Contains 2 EF-hand domains.,subcellular location:A small fraction of the protein may be cytoplasmic.,subunit:Interacts with GNAI2 and GNAI3.,tissue specificity:Expressed both in fetal and adult heart, lung, liver, kidney and brain, and in adult skeletal muscle, placenta and pancreas.,
Human protein sequence Database
Q02818
Mouse protein sequence database
Q02819
Rat protein sequence database
Q63083
Cellular localization
Golgi apparatus, cis-Golgi network membrane ; Peripheral membrane protein ; Lumenal side . Cytoplasm . Secreted . A small fraction of the protein may be cytoplasmic. .
Tissue expression
Expressed both in fetal and adult heart, lung, liver, kidney and brain, and in adult skeletal muscle, placenta and pancreas.
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