Immunogen
Synthesized peptide derived from human ESX1 AA range: 327-377
Specificity
This antibody detects endogenous levels of ESX1 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010],
Function
similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Expressed in placenta and testis.,
Gene Name
ESX1 ESX1L ESX1R
Fields
>>Signaling pathways regulating pluripotency of stem cells
Human protein sequence Database
Q8N693
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
Tissue expression
Expressed in placenta and testis. Expressed in testicular germ cell tumors.
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