Immunogen
Synthesized peptide derived from human ANO3 AA range: 518-568
Specificity
This antibody detects endogenous levels of ANO3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015],
Function
function:May act as a calcium-activated chloride channel.,similarity:Belongs to the anoctamin family.,
Gene Name
ANO3 C11orf25 TMEM16C GENX-3947
Human protein sequence Database
Q9BYT9
Mouse protein sequence database
A2AHL1
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein . Shows an intracellular localization. .
Tissue expression
Highly expressed in the forebrain striatum.
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