Immunogen
Synthesized peptide derived from human HME2 AA range: 225-275
Specificity
This antibody detects endogenous levels of HME2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008],
Function
disease:Genetic variations in EN2 may be associated with susceptibility to autism type 10 (AUTS10) [MIM:611016]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical and ritualized patterns of interests and behavior.,similarity:Belongs to the engrailed homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,
Human protein sequence Database
P19622
Mouse protein sequence database
P09066
Rat protein sequence database
Cellular localization
Nucleus.
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