Immunogen
Synthesized peptide derived from human NUD11 AA range: 83-133
Specificity
This antibody detects endogenous levels of NUD11 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008],
Function
catalytic activity:Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.,cofactor:Magnesium or manganese. Manganese may be the true cofactor in vivo.,function:Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyzes the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.,similarity:Belongs to the Nudix hydrolase family. DIPP subfamily.,tissue specificity:Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is also expressed in pancreas and weakly expressed in thymus, prostate, ovary, lung, small intestine and heart.,
Gene Name
NUDT11 APS1 DIPP3B
Human protein sequence Database
Q96G61
Mouse protein sequence database
P0C028
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is also expressed in pancreas and weakly expressed in thymus, prostate, ovary, lung, small intestine and heart.
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