Immunogen
Synthesized peptide derived from human CLPX AA range: 328-378
Specificity
This antibody detects endogenous levels of CLPX at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015],
Function
function:ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of clpP.,similarity:Belongs to the clpX chaperone family.,subunit:Heterodimer of clpP and clpX.,tissue specificity:Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas.,
Human protein sequence Database
O76031
Mouse protein sequence database
Q9JHS4
Rat protein sequence database
Q5U2U0
Cellular localization
Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.
Tissue expression
Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas.
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