Immunogen
Synthesized peptide derived from human PARVA AA range: 178-228
Specificity
This antibody detects endogenous levels of PARVA at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010],
Function
function:Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.,similarity:Belongs to the parvin family.,similarity:Contains 2 CH (calponin-homology) domains.,subcellular location:Constituent of focal adhesions.,subunit:Interacts with TGFB1I1 (By similarity). Interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Interacts with CDGAP.,tissue specificity:Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.,
Human protein sequence Database
Q9NVD7
Mouse protein sequence database
Q9EPC1
Rat protein sequence database
Q9HB97
Cellular localization
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line . Constituent of focal adhesions. Associates with the actin cytoskeleton.
Tissue expression
Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.
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