Immunogen
Synthesized peptide derived from human DHX16 AA range: 216-266
Specificity
This antibody detects endogenous levels of DHX16 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009],
Function
function:Probable ATP-binding RNA helicase involved in pre-mRNA splicing.,similarity:Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,
Gene Name
DHX16 DBP2 DDX16 KIAA0577
Human protein sequence Database
O60231
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus . Nucleus, nucleoplasm .
Tissue expression
Expressed in the spleen, thyroid and testis. Also expressed in the brain and cerebellum.
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