Immunogen
Synthesized peptide derived from human NTCP2 AA range: 46-96
Specificity
This antibody detects endogenous levels of NTCP2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010],
Function
disease:Defects in SLC10A2 are a cause of primary bile acid malabsorption (PBAM) [MIM:601295]. PBAM is an idiopathic intestinal disorder associated with congenital diarrhea, steatorrhea, interruption of the enterohepatic circulation of bile acids, and reduced plasma cholesterol levels.,function:Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism.,similarity:Belongs to the sodium:bile acid symporter family.,subunit:Monomer and homodimer.,
Gene Name
SLC10A2 ASBT ISBT NTCP2
Human protein sequence Database
Q12908
Mouse protein sequence database
P70172
Rat protein sequence database
Q62633
Cellular localization
Membrane; Multi-pass membrane protein.
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