Immunogen
Synthesized peptide derived from human KCNK2 AA range: 219-269
Specificity
This antibody detects endogenous levels of KCNK2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:Outward rectifying potassium channel.,miscellaneous:Activated by volatile general anesthetics such as chloroform, halothane and isoflurane.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,subunit:Homodimer .,
Gene Name
KCNK2 TREK TREK1
Fields
>>Cortisol synthesis and secretion;>>Cushing syndrome;>>Gastric acid secretion
Human protein sequence Database
O95069
Mouse protein sequence database
P97438
Rat protein sequence database
Cellular localization
[Isoform 1]: Cell membrane ; Multi-pass membrane protein .; [Isoform 2]: Cell membrane ; Multi-pass membrane protein .; [Isoform 4]: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue expression
Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra.
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