Immunogen
Synthesized peptide derived from human S61A1 AA range: 333-383
Specificity
This antibody detects endogenous levels of S61A1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008],
Function
function:Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins.,similarity:Belongs to the secY/SEC61-alpha family.,subunit:Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.,
Fields
>>Protein export;>>Protein processing in endoplasmic reticulum;>>Phagosome;>>Vibrio cholerae infection
Human protein sequence Database
P61619
Mouse protein sequence database
P61620
Rat protein sequence database
P61621
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Localizes exclusively in granular structures in the endoplasmic reticulum (ER). .
Tissue expression
Expressed in proximal and distal tubules in kidney (at protein level).
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