Immunogen
Synthesized peptide derived from human VPRBP AA range: 804-854
Specificity
This antibody detects endogenous levels of VPRBP at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
domain:Although not canonical, the WD repeat-like region is related to WD repeats.,function:May act as a receptor for CUL4-DDB1 ubiquitin ligase complex. In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr, possibly leading to hijack the RBX1-CUL4-DDB2 and arrest the cell cycle in G2 phase.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the VPRBP family.,similarity:Contains 1 LisH domain.,subunit:Interacts with DDB1, suggesting that it may participate to some RBX1-CUL4-DDB2 ubiquitin ligase complex. In case of infection, interacts with HIV-1 virus Vpr protein and forms a ternary complex with HIV-1 Vpr and DDB1.,tissue specificity:Ubiquitously expressed.,
Gene Name
VPRBP DCAF1 KIAA0800 RIP
Fields
>>Human immunodeficiency virus 1 infection
Human protein sequence Database
Q9Y4B6
Mouse protein sequence database
Q80TR8
Rat protein sequence database
Cellular localization
Cytoplasm. Nucleus. Associated with chromatin in a DDB1-independent and cell cycle-dependent manner: recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis.
Tissue expression
Ubiquitously expressed.
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