Immunogen
Synthesized peptide derived from human CHIC2 AA range: 111-161
Specificity
This antibody detects endogenous levels of CHIC2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich hydrophobic (CHIC) motif, and is localized to vesicular structures and the plasma membrane. This gene is associated with some cases of acute myeloid leukemia. [provided by RefSeq, Jul 2008],
Function
disease:A chromosomal aberration involving CHIC2 is found in a form of acute myeloid leukemia (AML). Translocation t(4;12)(q12;p13) with ETV6.,PTM:Palmitoylation in the CHIC motif is required for membrane association.,similarity:Belongs to the CHIC family.,subcellular location:Also present at a Golgi-like vesicular compartment and at scattered vesicles.,
Human protein sequence Database
Q9UKJ5
Mouse protein sequence database
Q9D9G3
Rat protein sequence database
Cellular localization
Cell membrane . Cytoplasmic vesicle . Also present at a Golgi-like vesicular compartment and at scattered vesicles.
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