Immunogen
Synthesized peptide derived from human PDE6D AA range: 89-139
Specificity
This antibody detects endogenous levels of PDE6D at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants. [provided by RefSeq, Mar 2014],
Function
similarity:Belongs to the PDE6D/unc-119 family.,subunit:Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain. Interacts with RPGR, ARL2 and ARL3.,tissue specificity:Retina.,
Fields
>>Purine metabolism;>>Metabolic pathways
Human protein sequence Database
O43924
Mouse protein sequence database
O55057
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol . Cytoplasmic vesicle membrane ; Peripheral membrane protein . Cytoplasm, cytoskeleton, cilium basal body .
Tissue expression
Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood.
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