Immunogen
Synthesized peptide derived from human UD11 AA range: 36-86
Specificity
This antibody detects endogenous levels of UD11 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008],
Function
alternative products:A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues,alternative products:A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues,catalytic activity:UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in UGT1A1 are the cause of Crigler-Najjar syndrome type I (CN-I) [MIM:218800]. CN-I patients have severe hyperbilirubinemia and usually die of kernicterus (bilirubin accumulation in the basal ganglia and brainstem nuclei) within the first year of life. CN-I inheritance is autosomal recessive.,disease:Defects in UGT1A1 are the cause of Crigler-Najjar syn
Gene Name
UGT1A1 GNT1 UGT1
Fields
>>Pentose and glucuronate interconversions;>>Ascorbate and aldarate metabolism;>>Steroid hormone biosynthesis;>>Retinol metabolism;>>Porphyrin metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Drug metabolism - cytochrome P450;>>Drug metabolism - other enzymes;>>Metabolic pathways;>>Biosynthesis of cofactors;>>Bile secretion;>>Chemical carcinogenesis - DNA adducts;>>Chemical carcinogenesis - receptor activation
Human protein sequence Database
P22309
Mouse protein sequence database
Q63886
Rat protein sequence database
Q64550
Cellular localization
Endoplasmic reticulum membrane ; Single-pass membrane protein . Cytoplasm, perinuclear region .
Tissue expression
[Isoform 1]: Expressed in liver, colon and small intestine. Not expressed in kidney, esophagus and skin. ; [Isoform 2]: Expressed in liver, colon, small intestine and kidney. Not expressed in esophagus and skin.
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