Immunogen
Synthesized peptide derived from human ISG20 AA range: 87-137
Specificity
This antibody detects endogenous levels of ISG20 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
catalytic activity:Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.,cofactor:Manganese.,function:Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses.,induction:Induced by interferons alpha and beta. Weaker induction was seen with interferon gamma. Increased expression was seen at the transcriptional level.,miscellaneous:Stable and constitutive expression confers resistance to vesicular stomatitis virus (VSV), influenza virus, and encephalomyocarditis virus (EMCV) infection in HeLa cells, providing an alternative antiviral pathway against RNA genomic viruses. Up regulated by E2 in estrogen receptor-positive breast cancer lines.,similarity:Belongs to the exonucl
Human protein sequence Database
Q96AZ6
Mouse protein sequence database
Q9JL16
Rat protein sequence database
Cellular localization
Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body.
Tissue expression
Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车