Immunogen
Synthesized peptide derived from human DGAT1 AA range: 405-455
Specificity
This antibody detects endogenous levels of DGAT1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013],
Function
catalytic activity:Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.,function:Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly.,pathway:Lipid metabolism; glycerolipid metabolism.,similarity:Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.,
Gene Name
DGAT1 AGRP1 DGAT
Fields
>>Glycerolipid metabolism;>>Retinol metabolism;>>Metabolic pathways;>>Fat digestion and absorption
Human protein sequence Database
O75907
Mouse protein sequence database
Q9Z2A7
Rat protein sequence database
Q9ERM3
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
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