Immunogen
Synthesized peptide derived from human PPT2 AA range: 198-248
Specificity
This antibody detects endogenous levels of PPT2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011],
Function
caution:Was originally (PubMed:9341199) referred as a palmitoyl-protein thioesterase (palmitoyl-protein hydrolase).,function:Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.,similarity:Belongs to the palmitoyl-protein thioesterase family.,tissue specificity:Broadly expressed, with highest levels in skeletal muscle.,
Fields
>>Fatty acid elongation;>>Metabolic pathways;>>Fatty acid metabolism;>>Lysosome
Human protein sequence Database
Q9UMR5
Mouse protein sequence database
O35448
Rat protein sequence database
O70489
Cellular localization
Lysosome .
Tissue expression
Broadly expressed, with highest levels in skeletal muscle.
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