Immunogen
Synthesized peptide derived from human SPS1 AA range: 323-373
Specificity
This antibody detects endogenous levels of SPS1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010],
Function
catalytic activity:ATP + selenide + H(2)O = AMP + selenophosphate + phosphate.,caution:The conserved active site Cys (or selenocysteine) residue in position 29 is replaced by a Thr. However, as function in selenoprotein synthesis is proven, it is possible Cys-31 is the active site.,function:Synthesizes selenophosphate from selenide and ATP.,similarity:Belongs to the selenophosphate synthetase 1 family. Class II subfamily.,
Gene Name
SEPHS1 SELD SPS SPS1
Fields
>>Selenocompound metabolism;>>Metabolic pathways
Human protein sequence Database
P49903
Mouse protein sequence database
Q8BH69
Rat protein sequence database
Cellular localization
[Isoform 1]: Cell membrane ; Peripheral membrane protein . Nucleus membrane ; Peripheral membrane protein .; [Isoform 2]: Cytoplasm .; [Isoform 3]: Cytoplasm .; [Isoform 4]: Cytoplasm .
Tissue expression
[Isoform 1]: Gradually expressed during the cell cycle until G2/M phase and then decreases. ; [Isoform 2]: Gradually expressed during the cell cycle until G2/M phase and then decreases. ; [Isoform 3]: Gradually expressed during the cell cycle until S phase and then decreases.
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