Immunogen
Synthesized peptide derived from human NUP54 AA range: 98-148
Specificity
This antibody detects endogenous levels of NUP54 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013],
Function
domain:Contains FG repeats.,function:Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.,PTM:O-glycosylated.,similarity:Belongs to the NUP54 family.,subcellular location:Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter.,subunit:Component of the p62 complex, a complex composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUPL1.,
Fields
>>Nucleocytoplasmic transport;>>Amyotrophic lateral sclerosis
Human protein sequence Database
Q7Z3B4
Mouse protein sequence database
Q8BTS4
Rat protein sequence database
P70582
Cellular localization
Nucleus, nuclear pore complex . Nucleus membrane ; Peripheral membrane protein ; Cytoplasmic side . Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side . Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter. .
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