Immunogen
Synthesized peptide derived from human STX3 AA range: 6-56
Specificity
This antibody detects endogenous levels of STX3 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010],
Function
function:Potentially involved in docking of synaptic vesicles at presynaptic active zones.,similarity:Belongs to the syntaxin family.,similarity:Contains 1 t-SNARE coiled-coil homology domain.,
Fields
>>SNARE interactions in vesicular transport;>>Synaptic vesicle cycle
Human protein sequence Database
Q13277
Mouse protein sequence database
Q64704
Rat protein sequence database
Q08849
Cellular localization
[Isoform A]: Apical cell membrane ; Single-pass type IV membrane protein . Localized to the inner and outer plexiform layers, the cell body and the inner segments of photoreceptors. .; [Isoform 3]: Nucleus .
Tissue expression
[Isoform A]: Expressed in small intestine, kidney, pancreas, placenta as well as in retina. Weaker expression in lung, liver and heart. Not expressed in brain and skeletal muscle. ; [Isoform B]: Expressed only in the retina. ; [Isoform 3]: Ubiquitously expressed.
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