Immunogen
Synthesized peptide derived from human AIP AA range: 251-301
Specificity
This antibody detects endogenous levels of AIP at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014],
Function
disease:Defects in AIP are a cause of ACTH-secreting pituitary adenoma [MIM:219090]; also known as pituitary Cushing disease. Cushing disease is a condition associated with increased blood cortisol resulting from adrenocorticotropic hormone (ACTH)-producing pituitary tumors that are resistant to glucocorticoid negative feedback.,disease:Defects in AIP are a cause of familial isolated pituitary adenoma (FIPA) [MIM:102200].,disease:Defects in AIP are a cause of growth hormone-secreting pituitary adenoma [MIM:102200]; also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma.,disease:Defects in AIP are a cause of pituitary adenoma predisposition (PAP) [MIM:102200].,function:Cellular negative regulator of the hepatitis B virus (HBV) X protein.,function:May play a positive role in AHR-m
Fields
>>Cushing syndrome;>>Chemical carcinogenesis - receptor activation
Human protein sequence Database
O00170
Mouse protein sequence database
O08915
Rat protein sequence database
Q5FWY5
Cellular localization
Cytoplasm.
Tissue expression
Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.
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