Immunogen
Synthesized peptide derived from human MTMR5 AA range: 320-370
Specificity
This antibody detects endogenous levels of MTMR5 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the protein-tyrosine phosphatase family. However, the encoded protein does not appear to be a catalytically active phosphatase because it lacks several amino acids in the catalytic pocket. This protein contains a Guanine nucleotide exchange factor (GEF) domain which is necessary for its role in growth and differentiation. Mutations in this gene have been associated with Charcot-Marie-Tooth disease 4B3. Pseudogenes of this gene have been defined on chromosomes 1 and 8. [provided by RefSeq, Dec 2014],
Function
function:Probable pseudophosphatase. Lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.,similarity:Contains 1 dDENN domain.,similarity:Contains 1 DENN domain.,similarity:Contains 1 GRAM domain.,similarity:Contains 1 myotubularin phosphatase domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 uDENN domain.,subunit:Interacts with the SET domain of MLL/HRX. Interacts with SUV39H1.,
Human protein sequence Database
O95248
Mouse protein sequence database
Q6ZPE2
Rat protein sequence database
Cellular localization
Cytoplasm . Cytoplasm, perinuclear region .
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