Immunogen
Synthesized peptide derived from human CLC4E AA range: 46-96
Specificity
This antibody detects endogenous levels of CLC4E at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008],
Function
function:May play a role in the response to inflammatory stimuli in peritoneal macrophages. May be involved in immune surveillance processes under transcriptional control of CEBPB.,online information:Mincle,similarity:Contains 1 C-type lectin domain.,
Gene Name
CLEC4E CLECSF9 MINCLE UNQ218/PRO244
Fields
>>C-type lectin receptor signaling pathway;>>Tuberculosis
Human protein sequence Database
Q9ULY5
Mouse protein sequence database
Q9R0Q8
Rat protein sequence database
Q67EQ1
Cellular localization
Cell membrane ; Single-pass type II membrane protein . Cell projection, phagocytic cup .
Tissue expression
Expressed in monocytes and macrophages.
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