Immunogen
Synthesized peptide derived from human WFKN2 AA range: 506-556
Specificity
This antibody detects endogenous levels of WFKN2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008],
Function
function:Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin.,similarity:Belongs to the WFIKKN family.,similarity:Contains 1 BPTI/Kunitz inhibitor domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Kazal-like domain.,similarity:Contains 1 NTR domain.,similarity:Contains 1 WAP domain.,similarity:Contains 2 BPTI/Kunitz inhibitor domains.,subunit:Interacts with both mature and propeptide myostatin/MSTN.,tissue specificity:Primarily expressed in ovary, testis and brain, but not in liver. In fetal tissues, it is primarily expressed in brain, skeletal muscle, thymus and kidney.,
Gene Name
WFIKKN2 GASP1 WFIKKNRP UNQ9235/PRO31996
Human protein sequence Database
Q8TEU8
Mouse protein sequence database
Q7TQN3
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Primarily expressed in ovary, testis and brain, but not in liver. In fetal tissues, it is primarily expressed in brain, skeletal muscle, thymus and kidney.
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