Immunogen
Synthesized peptide derived from human SIA7D AA range: 194-244
Specificity
This antibody detects endogenous levels of SIA7D at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
catalytic activity:CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-(N-acetyl-alpha-neuraminyl-(2->6))-N-acetyl-D-galactosaminyl-R.,function:Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids.,online information:GlycoGene database,online information:ST6GalNAc IV,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 29 family.,tissue specificity:Ubiquitous.,
Gene Name
ST6GALNAC4 SIAT3C SIAT7D
Fields
>>Mucin type O-glycan biosynthesis;>>Glycosphingolipid biosynthesis - ganglio series;>>Metabolic pathways
Human protein sequence Database
Q9H4F1
Mouse protein sequence database
Q9R2B6
Rat protein sequence database
Cellular localization
Golgi apparatus membrane ; Single-pass type II membrane protein .
Tissue expression
Ubiquitous.
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