Immunogen
Synthesized peptide derived from human NMD3 AA range: 235-285
Specificity
This antibody detects endogenous levels of NMD3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Several transcript variants exist for this gene, but the full-length natures of only two have been described to date. [provided by RefSeq, Feb 2016],
Function
function:Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.,similarity:Belongs to the NMD3 family.,subcellular location:Shuttles between the nucleus/nucleolus and the cytoplasm in a XPO1/CRM1-dependent manner.,subunit:Found in a 60S ribosomal subunit export complex with RAN and XPO1. Interacts with XPO1. Associates with the 60S ribosomal subunit.,
Fields
>>Ribosome biogenesis in eukaryotes;>>Nucleocytoplasmic transport
Human protein sequence Database
Q96D46
Mouse protein sequence database
Q99L48
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Shuttles between the nucleus/nucleolus and the cytoplasm in a XPO1/CRM1-dependent manner. .
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