Immunogen
Synthesized peptide derived from human DDX47 AA range: 86-136
Specificity
This antibody detects endogenous levels of DDX47 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
similarity:Belongs to the DEAD box helicase family.,similarity:Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,
Human protein sequence Database
Q9H0S4
Mouse protein sequence database
Q9CWX9
Rat protein sequence database
Cellular localization
Nucleus, nucleolus . Localizes in the nucleolar-organizing region during ribosome biogenesis.
Tissue expression
Expressed in skin, lung and breast. Also expressed in the brain.
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