Immunogen
Synthesized peptide derived from human REST AA range: 593-643
Specificity
This antibody detects endogenous levels of human REST
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Protein name
RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor)
Fields
>>Signaling pathways regulating pluripotency of stem cells;>>Huntington disease
Human protein sequence Database
Q13127
Mouse protein sequence database
Q8VIG1
Rat protein sequence database
O54963
Cellular localization
Nucleus . Cytoplasm . Colocalizes with ZFP90 in the nucleus (By similarity). In response to hypoxia, there is a more pronounced increase in levels in the nucleus as compared to the cytoplasm (PubMed:27531581). In aging neurons, increased levels in the nucleus as compared to the cytoplasm (PubMed:24670762, PubMed:30684677). .; [Isoform 2]: Cytoplasm .; [Isoform 3]: Nucleus .; [Isoform 4]: Cytoplasm .
Tissue expression
Expressed in neurons of the prefrontal cortex, in hippocampal pyramidal neurons, dentate gyrus granule neurons and cerebellar Purkinje and granule neurons (at protein level) (PubMed:24670762). Expressed in dopaminergic neurons of the substantia nigra (at protein level) (PubMed:30684677). Expressed in neural progenitor cells (at protein level) (PubMed:21258371). In patients suffering from Alzheimer disease, frontotemporal dementia or dementia with Lewy bodies, decreased nuclear levels have been observed in neurons of the prefrontal cortex and the hippocampus, but not in neurons of the dentate gyrus and cerebellum (at protein level) (PubMed:24670762). In patients with Parkinson disease or dementia with Lewy bodies, decreased nuclear levels have been observed in dopaminergic neurons and in co
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车