Immunogen
Synthesized peptide derived from human DEDD2 AA range: 226-276
Specificity
This antibody detects endogenous levels of human DEDD2
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Gene Name
DEDD2 FLAME3 PSEC0004
Protein name
DNA-binding death effector domain-containing protein 2 (DED-containing protein FLAME-3) (FADD-like anti-apoptotic molecule 3)
Human protein sequence Database
Q8WXF8
Mouse protein sequence database
Q8QZV0
Rat protein sequence database
Cellular localization
Nucleus, nucleolus . Nuclear, accumulated in subnuclear structures resembling nucleoli.
Tissue expression
Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels.
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