Immunogen
Synthesized peptide derived from human ABI2 AA range: 61-111
Specificity
This antibody detects endogenous levels of human ABI2
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Protein name
Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
Fields
>>Regulation of actin cytoskeleton
Human protein sequence Database
Q9NYB9
Mouse protein sequence database
P62484
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus .; [Isoform 1]: Cell projection, lamellipodium . Cell projection, filopodium . Cytoplasm, cytoskeleton . Cell junction, adherens junction . Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips (PubMed:11516653, PubMed:15572692). Present at nascent adherens junctions, where it clusters adjacent to the tips of F-actin protrusions (PubMed:15572692). .
Tissue expression
Widely expressed. Abundant in testes, ovary, thymus, and colon, with lower but detectable levels in prostate, peripheral blood leukocytes, and spleen.
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