Immunogen
Synthesized peptide derived from human ATLA1 AA range: 460-510
Specificity
This antibody detects endogenous levels of human ATLA1
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Gene Name
ATL1 GBP3 SPG3A
Protein name
Atlastin-1 (EC 3.6.5.-) (Brain-specific GTP-binding protein) (GTP-binding protein 3) (GBP-3) (hGBP3) (Guanine nucleotide-binding protein 3) (Spastic paraplegia 3 protein A)
Human protein sequence Database
Q8WXF7
Mouse protein sequence database
Q8BH66
Rat protein sequence database
Q6PST4
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cell projection, axon . Localizes to endoplasmic reticulum tubular network (PubMed:27619977). .
Tissue expression
Expressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. Expressed in upper and lower motor neurons (at protein level).
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