Immunogen
Synthesized peptide derived from human RIF1 AA range: 1428-1478
Specificity
This antibody detects endogenous levels of human RIF1
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Protein name
Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)
Fields
>>Signaling pathways regulating pluripotency of stem cells
Human protein sequence Database
Q5UIP0
Mouse protein sequence database
Q6PR54
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Chromosome, telomere . Cytoplasm, cytoskeleton, spindle . Following interaction with TP53BP1, recruited to sites of DNA damage, such as DSBs (By similarity). Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs) (PubMed:15342490). Does not associate with normal telomere structures (PubMed:15342490, PubMed:15583028). Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase (PubMed:15583028). .
Tissue expression
Highly expressed in testis.
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