Immunogen
Synthesized peptide derived from human ENW1 AA range: 442-492
Specificity
This antibody detects endogenous levels of human ENW1
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Protein name
HERV-W_7q21.2 provirus ancestral Env polyprotein (Endogenous retrovirus group W member 1) (Env-W) (Envelope polyprotein gPr73) (Enverin) (HERV-7q Envelope protein) (HERV-W envelope protein) (Syncytin)
Human protein sequence Database
Q9UQF0
Mouse protein sequence database
Rat protein sequence database
Cellular localization
[Surface protein]: Cell membrane ; Peripheral membrane protein . The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. .; [Transmembrane protein]: Cell membrane ; Single-pass type I membrane protein .; [Syncytin-1]: Virion .
Tissue expression
Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.
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