Immunogen
Synthesized peptide derived from human MEFV AA range: 517-567
Specificity
This antibody detects endogenous levels of human MEFV
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Protein name
Pyrin (Marenostrin)
Fields
>>NOD-like receptor signaling pathway;>>Yersinia infection
Human protein sequence Database
O15553
Mouse protein sequence database
Q9JJ26
Rat protein sequence database
Q9JJ25
Cellular localization
[Isoform 1]: Cytoplasm, cytoskeleton . Cell projection, ruffle . Cell projection, lamellipodium . Nucleus . Cytoplasm . Cytoplasmic vesicle, autophagosome . Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles (PubMed:11468188). In pre-apoptotic cells, colocalizes with PYCARD/ASC in large specks (inflammasomes) (PubMed:11468188). In migrating monocytes, strongly polarized at the leading edge of the cell where it colocalizes with polymerizing actin and PYCARD/ASC (PubMed:11468188). .; [Isoform 2]: Nucleus .
Tissue expression
Expressed in peripheral blood leukocytes, particularly in mature granulocytes and to a lesser extent in monocytes but not in lymphocytes. Detected in spleen, lung and muscle, probably as a result of leukocyte infiltration in these tissues. Not expressed in thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, liver, kidney, pancreas. Expression detected in several myeloid leukemic, colon cancer, and prostate cancer cell lines.
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